Profitability of poultry farming depends upon various factors including faster growth of the birds, breast meat yield, efficiency of feed conversion, lower mortality and morbidity rates for broilers & increased egg production for layers. Com, soya, wheat bran, and other plant based materials are used as a major ingredients for poultry feed formulation. These ingredients are usually prone to toxigenic fungal attack, leading to contamination with single or multiple mycotoxins. It has been proved by various studies that mycotoxins are having carcinogenic, estrogenic, immunotoxic, nephrotoxic, hepatotoxic and neurotoxic effects on bird and the effect is more pronounced, when multiple mycotoxins are present. These effects can lead to a significant loss in profitability of poultry farming. In addition to the direct toxic effect on the host cells, mycotoxins have a negative effect on beneficial gut microflora also. Mycotoxin are hazardous metabolites of molds (fungi) that are usually found in feed. They are known to exert toxic effects in animals and humans. Mycotoxigenic fungi infect crops in the field and during storage. Aflatoxins particularly aflatoxin B1, are among the most common mycotoxins in com, which is the most important feed grain. Mycotoxins contamination results in the loss of nutritive value of feedstuffs and leads to mycotoxicosis, which varies from acute diseases with a high morbidity to chronic disorders with reduced animal productivity.